Research on ADR1s helps understanding the plant immune network

Abstract Plant innate immunity begins with the recognition of pathogens by plasma membrane localized pattern-recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat containing (NLRs), which lead to pattern-triggered (PTI) effector-triggered (ETI), respectively. For a long time, PTI ETI have been regarded as two independent processes although they share multiple components signal outputs. Increasing evidence shows an intimate link between ETI. mutually potentiate each other, this is essential for robust disease resistance during pathogen infection. An ancient class NLRs called RNLs, so named because carry Resistance Powdery Mildew 8 (RPW8)-like coiled-coil (CC) in N terminus, has emerged key node connecting RNLs not only act helper that downstream sensor NLRs, also directly mediate signaling associating PRR complexes. Here, we focus on Activated Disease 1 (ADR1), subclass discuss its role mechanism plant immunity.